Uithuizermeeden came into being in the 12th century below the North Sea coastal dyke. The Mariakerk, or Mary's Church, built in the second half of the 13th century, stands in the centre of the village. It was renovated during the 19th century and given its Neo-Classical appearance, and the walls were plastered white. The tower was built in 1717 by master builder Allert Meijer, who also designed the tower of Der Aa-kerk in Groningen, which can be clearly seen in the corresponding building styles. The village municipal hall is also a striking building. This was designed by Groningen architect Adrianus van Wissen.The Rensuma estate is located in Uithuizermeeden. The estate manor house was built around 1500, but was thoroughly renovated in 1710 and given its current appearance. For many years the building functioned as a horticultural college. The estate house was restored to its former glory in 1996. While the house itself is cannot be viewed on the inside, the estate around it is open to the public. The visitors' garden and tea house BijTrix is located to the north-east of the village. Slightly further to the north is the 'northern cape': the most northerly point of the Dutch mainland, where from the dyke you can see the island of Rottumeroog.