When arriving to Sisimiut you can go by bus to the center of Sisimiut. Here you can view the bus schedule (Danish only).
Getting thereFlight with Air Greenland from Copenhagen to Kangerlussuaq. From there a short shuttle trip with Air Greenland
There are no inter-connecting roads in Greenland between towns, but you can rent a car here (in Danish only) in Sisimiut for driving in Sisimiut only.